Ship I I, Miller M F, Ram C
Oral Surg Oral Med Oral Pathol. 1977 Nov;44(5):723-30. doi: 10.1016/0030-4220(77)90382-6.
A retrospective 12-year investigation of 1,788 professional school students from the schools of medicine, veterinary medicine, dental medicine, nursing, and dental hygiene was conducted by the mailed distribution of questionnaires requesting information on current and prior disease history of recurrent herpes labialis (RHL). Because of changes in address, death, loss of married names, and unwillingness to participate in the investigation, only 683 proband subjects were available for the follow-up study. The data suggested a trend toward a decrease in the prevalence and severity of RHL during the interval of study: only slightly more than one firth (23.9 per cent) of the proband population of the present study experienced RHL as compared with almost two fifths (39.6 per cent) at the time when they were students.
通过邮寄问卷的方式，对来自医学院、兽医学院、牙医学院、护理学院和口腔卫生学院的1788名专业院校学生进行了一项为期12年的回顾性调查，问卷要求提供有关复发性唇疱疹（RHL）的当前和既往病史信息。由于地址变更、死亡、婚后姓氏丢失以及不愿参与调查等原因，仅有683名先证者可供后续研究。数据表明，在研究期间，RHL的患病率和严重程度呈下降趋势：本研究中先证者群体中仅有略多于五分之一（23.9%）的人经历过RHL，而他们在学生时期这一比例接近五分之二（39.6%）。
