Leveque Yohana, Fauvel Baptiste, Groussard Mathilde, Caclin Anne, Albouy Philippe, Platel Hervé, Tillmann Barbara
Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France; University Lyon 1, Lyon, France;
INSERM U1077, Caen, France; and Université de Caen Basse-Normandie, UMR-S1077, Caen, France.
J Neurophysiol. 2016 Jul 1;116(1):88-97. doi: 10.1152/jn.00663.2015. Epub 2016 Mar 23.
Congenital amusia, a neurodevelopmental disorder of music perception and production, has been associated with abnormal anatomical and functional connectivity in a right frontotemporal pathway. To investigate whether spontaneous connectivity in brain networks involving the auditory cortex is altered in the amusic brain, we ran a seed-based connectivity analysis, contrasting at-rest functional MRI data of amusic and matched control participants. Our results reveal reduced frontotemporal connectivity in amusia during resting state, as well as an overconnectivity between the auditory cortex and the default mode network (DMN). The findings suggest that the auditory cortex is intrinsically more engaged toward internal processes and less available to external stimuli in amusics compared with controls. Beyond amusia, our findings provide new evidence for the link between cognitive deficits in pathology and abnormalities in the connectivity between sensory areas and the DMN at rest.
先天性失歌症是一种音乐感知和产生方面的神经发育障碍，与右侧额颞叶通路中异常的解剖结构和功能连接有关。为了研究涉及听觉皮层的脑网络中的自发连接在失歌症患者大脑中是否发生改变，我们进行了基于种子点的连接性分析，对比了失歌症患者和匹配的对照参与者的静息态功能磁共振成像数据。我们的结果显示，在静息状态下，失歌症患者的额颞叶连接减少，以及听觉皮层与默认模式网络（DMN）之间存在过度连接。这些发现表明，与对照组相比，失歌症患者的听觉皮层在本质上更多地参与内部过程，而对外部刺激的反应较少。除了失歌症，我们的发现为病理学中的认知缺陷与静息状态下感觉区域和DMN之间连接异常之间的联系提供了新的证据。
