Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
INSERM UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France.
Cardiovasc Res. 2016 Jun 1;110(3):298-308. doi: 10.1093/cvr/cvw061. Epub 2016 Mar 22.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.
心血管疾病（CVDs）是全球范围内的主要死亡原因，也是公共卫生的主要问题。多年来，全球的预期寿命显著增加，随着人口老龄化的加剧，CVD 的患病率不可避免地上升。正常的衰老过程与血管结构和功能的进行性恶化有关，通常称为血管衰老。在血管水平上，细胞外基质（ECM）的衰老导致长半衰期蛋白（如弹性蛋白和胶原蛋白）的分子改变，并对血管疾病有重要影响。本综述重点介绍了血管衰老过程中 ECM 的改变，特别是弹性蛋白片段化以及弹性蛋白衍生肽（EDP）在与年龄相关的血管并发症中的作用。此外，还讨论了目前和新的旨在最小化弹性蛋白降解、EDP 生成和相关生物学效应的药理学策略。这些策略对于预防和/或延迟血管衰老及其并发症可能具有重要意义。
