Dbouk Hashem A, Huang Chou-Long, Cobb Melanie H
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and.
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F16-27. doi: 10.1152/ajprenal.00358.2015. Epub 2016 Mar 23.
The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.
无赖氨酸[K]（WNK）酶家族在血压调节中起核心作用。WNK与遗传性高血压疾病有关，主要是通过控制离子共转运体和通道的活性及水平。WNK在肾脏中的作用已得到深入研究，最近的研究不仅深入了解了这些酶的调节机制，还揭示了WNK及其相互作用伴侣的突变如何导致高血压疾病。明确WNK在心血管系统中的作用将为WNK调节血压的其他机制提供线索。本综述总结了WNK信号级联调节的最新进展及其在血压调节中的作用。
