Freire de Moura Maria, Flores-Guevara Roberto, Gueguen Bernard, Biraben Arnaud, Renault Francis
Neurophysiology Unit, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Pediatric Neurophysiology Unit, Armand-Trousseau Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Epilepsia. 2016 May;57(5):e94-6. doi: 10.1111/epi.13352. Epub 2016 Mar 24.
The recognizable electroencephalography (EEG) pattern of ring chromosome 20 epilepsy syndrome can be missing in patients with r(20) chromosomal anomaly, and may be found in patients with frontal lobe epilepsy of other origin. This study aims to search for more specific EEG signs by using long-term recordings and measuring the duration of paroxysmal anomalies. The series included 12 adult patients with r(20) anomaly, and 12 controls without any chromosomal aberration. We measured the duration of every paroxysmal burst and calculated the sum of their durations for each long-term EEG recording. We compared patients to controls using the Mann-Whitney U-test. Every patient showed long-lasting paroxysmal EEG bursts, up to 60 min; controls did not show any bursts longer than 60 s (p < 0.0001). The total duration of paroxysmal anomalies was significantly longer in patients (31-692 min) compared to controls (0-48 min) (p < 0.0001). Thus, long-term recordings enhance the contribution of EEG methods for characterizing the ring 20 chromosome epilepsy syndrome.
20号环状染色体癫痫综合征可识别的脑电图（EEG）模式在患有r(20)染色体异常的患者中可能缺失，而在其他原因引起的额叶癫痫患者中可能出现。本研究旨在通过长期记录和测量阵发性异常的持续时间来寻找更具特异性的脑电图体征。该系列研究纳入了12例患有r(20)异常的成年患者和12例无任何染色体畸变的对照者。我们测量了每次阵发性发作的持续时间，并计算了每次长期脑电图记录中这些发作持续时间的总和。我们使用曼-惠特尼U检验对患者和对照者进行比较。每位患者均表现出持续时间长达60分钟的持续性阵发性脑电图发作；对照者未出现任何持续时间超过60秒的发作（p < 0.0001）。与对照者（0 - 48分钟）相比，患者阵发性异常的总持续时间显著更长（31 - 692分钟）（p < 0.0001）。因此，长期记录增强了脑电图方法在表征20号环状染色体癫痫综合征方面的作用。
