Leone Angelique M, Crawshaw Graham J, Garner Michael M, Frasca Salvatore, Stasiak Iga, Rose Karrie, Neal Dan, Farina Lisa L
J Zoo Wildl Med. 2016 Mar;47(1):45-55. doi: 10.1638/2015-0224.1.
Egyptian fruit bats (Rousettus aegyptiacus) are one of many species within zoologic collections that frequently develop iron storage disease. The goals of this retrospective multi-institutional study were to determine the tissue distribution of iron storage in captive adult Egyptian fruit bats and the incidence of intercurrent neoplasia and infection, which may be directly or indirectly related to iron overload. Tissue sections from 83 adult Egyptian fruit bats were histologically evaluated by using tissue sections stained with hematoxylin and eosin, trichrome, and Prussian blue techniques. The liver and spleen consistently had the largest amount of iron, but significant amounts of iron were also detected in the pancreas, kidney, skeletal muscle, and lung. Hepatocellular carcinoma (HCC; 11) was the most common neoplasm, followed by cholangiocarcinoma (4). Extrahepatic neoplasms included bronchioloalveolar adenoma (3), pulmonary carcinosarcoma (1), oral sarcoma (1), renal adenocarcinoma (1), transitional cell carcinoma of the urinary bladder (1), mammary gland adenoma (1), and parathyroid adenoma (1). There were also metastatic neoplasms of undetermined primary origin that included three poorly differentiated carcinomas, a poorly differentiated sarcoma, and a neuroendocrine tumor. Bats with hemochromatosis were significantly more likely to have HCC than bats with hemosiderosis (P = 0.032). Cardiomyopathy was identified in 35/77 bats with evaluable heart tissue, but no direct association was found between cardiac damage and the amount of iron observed within the liver or heart. Hepatic abscesses occurred in multiple bats, although a significant association was not observed between hemochromatosis and bacterial infection. To the authors' knowledge, this is the first publication providing evidence of a positive correlation between hemochromatosis and HCC in any species other than humans.
埃及果蝠（埃及果蝠属）是动物收藏中经常发生铁储存疾病的众多物种之一。这项回顾性多机构研究的目的是确定圈养成年埃及果蝠中铁储存的组织分布以及并发肿瘤和感染的发生率，这些可能与铁过载直接或间接相关。对83只成年埃及果蝠的组织切片进行组织学评估，采用苏木精和伊红、三色染色和普鲁士蓝技术染色的组织切片。肝脏和脾脏始终含有最多的铁，但在胰腺、肾脏、骨骼肌和肺中也检测到大量铁。肝细胞癌（HCC；11例）是最常见的肿瘤，其次是胆管癌（4例）。肝外肿瘤包括细支气管肺泡腺瘤（3例）、肺肉瘤（1例）、口腔肉瘤（1例）、肾腺癌（1例）、膀胱移行细胞癌（1例）、乳腺腺瘤（1例）和甲状旁腺瘤（1例）。还有一些原发灶不明的转移性肿瘤，包括3例低分化癌、1例低分化肉瘤和1例神经内分泌肿瘤。与患有含铁血黄素沉着症的蝙蝠相比，患有血色素沉着症的蝙蝠患HCC的可能性显著更高（P = 0.032）。在77只心脏组织可评估的蝙蝠中，有35只被诊断出患有心肌病，但未发现心脏损伤与肝脏或心脏中观察到的铁含量之间存在直接关联。多只蝙蝠发生肝脓肿，尽管未观察到血色素沉着症与细菌感染之间存在显著关联。据作者所知，这是第一份提供除人类以外任何物种血色素沉着症与HCC之间正相关证据的出版物。
