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一只短尾猫(猞猁属)在类似Chiari畸形的手术矫正后出现进行性脊髓空洞症和变性轴索性神经病。

PROGRESSIVE SYRINGOHYDROMYELIA AND DEGENERATIVE AXONOPATHY IN A BOBCAT (LYNX RUFUS) FOLLOWING SURGICAL CORRECTION OF A CHIARI-LIKE MALFORMATION.

作者信息

Sadler Ryan, Schumacher Juergen, Ramsay Edward, McCleery Brynn, Baine Katherine, Thomas William, Nobrega-Lee Michelle, Henry George A, Newman Shelley J

出版信息

J Zoo Wildl Med. 2016 Mar;47(1):329-32. doi: 10.1638/2014-0149.1.

DOI:10.1638/2014-0149.1
PMID:27010296
Abstract

A 3-yr-old male captive bobcat (Lynx rufus) presented with chronic ataxia and right-sided head tilt. Magnetic resonance imaging (MRI) revealed cerebellar crowding and compression consistent with Chiari-like malformation. The clinical signs did not improve after surgical occipital craniectomy, and 2 mo postoperatively a second MRI showed hydromyelia and continued cerebellar compression. The bobcat was euthanized, and necropsy showed chronic focal cerebellar herniation and chronic multifocal atlanto-occipital joint osteophyte proliferation. Histology confirmed the presence of a thick fibrous membrane along the caudal aspect of the cerebellar vermis, suggestive of postoperative adhesions, and axonal degeneration of the cervical spinal cord, even in sections without a central canal lesion. These lesions appear to have been complications associated with surgical correction of the Chiari-like malformation.

摘要

一只3岁的圈养雄性短尾猫(猞猁属)出现慢性共济失调和右侧头部倾斜。磁共振成像(MRI)显示小脑拥挤和受压,符合 Chiari 样畸形。枕骨颅骨切除术后临床症状未改善,术后2个月第二次MRI显示脊髓空洞症和小脑持续受压。该短尾猫实施了安乐死,尸检显示慢性局灶性小脑疝和慢性多灶性寰枕关节骨赘增生。组织学证实沿小脑蚓部尾侧有一层厚厚的纤维膜,提示术后粘连,以及颈脊髓轴突退变,即使在没有中央管病变的切片中也是如此。这些病变似乎是 Chiari 样畸形手术矫正相关的并发症。

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