Hruby Z
Wiad Lek. 1989;42(16-18):963-9.
In the treatment of nephrotic syndromes complicating primary glomerulonephritis anti-inflammatory and immunosuppressive action of glucocorticoids is used most frequently. Cases refractory to corticotherapy are a difficult clinical problem and lead, most frequently, to renal failure. Recently trials have been carried out of replacing glucocorticoids with the immunosuppressant which is devoid of the dangerous side effects of cytostatics, i.e. cyclosporin A. Theoretical and experimental data relevant to the use of cyclosporin A in the treatment of glomerulopathies are presented and the results of clinical studies carried out as yet, and therapeutic prospects are discussed.
在原发性肾小球肾炎并发肾病综合征的治疗中，糖皮质激素的抗炎和免疫抑制作用最为常用。对皮质激素治疗无效的病例是一个棘手的临床问题，且最常导致肾衰竭。最近已开展了用免疫抑制剂替代糖皮质激素的试验，该免疫抑制剂没有细胞抑制剂的危险副作用，即环孢素A。本文介绍了与环孢素A用于治疗肾小球病相关的理论和实验数据、迄今开展的临床研究结果，并讨论了治疗前景。
