Hsu Peter S, Campbell Dianne E
Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney.
Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney.
Paediatr Respir Rev. 2016 Jun;19:69-74. doi: 10.1016/j.prrv.2016.02.002. Epub 2016 Feb 23.
The increase in allergic airways disease has been linked to modern urbanization and lifestyle. Recent evidence suggests that the associated reduction in microbial exposure, reduction in dietary fibre intake and increased antibiotic use may cause early dysbiosis in infancy, which predisposes to immune dysregulation and allergic airways disease later in life. This implies that there may be a window of opportunity for primary prevention strategies aimed to protect or restore the microbiome early in life and thereby decrease the risk of developing allergic airways disease. Alternatively, strategies that correct dysbiosis may aid in the treatment of established allergic airways disease.
过敏性气道疾病的增加与现代城市化和生活方式有关。最近的证据表明，与之相关的微生物接触减少、膳食纤维摄入量减少以及抗生素使用增加，可能会导致婴儿期早期的生态失调，从而使个体在以后的生活中易患免疫失调和过敏性气道疾病。这意味着，可能存在一个机会窗口，可采取一级预防策略，旨在在生命早期保护或恢复微生物群，从而降低患过敏性气道疾病的风险。另外，纠正生态失调的策略可能有助于治疗已确诊的过敏性气道疾病。
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