Department of Microbiology & Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
J Allergy Clin Immunol. 2019 Dec;144(6):1638-1647.e3. doi: 10.1016/j.jaci.2019.06.029. Epub 2019 Jul 3.
Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance.
We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children.
We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, before their developing allergic disease.
We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production.
Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.
过敏疾病是儿童最常见的慢性健康问题，与生命早期肠道微生物失调有关。有许多证据表明，微生物衍生的短链脂肪酸，特别是丁酸盐，可以促进免疫耐受。
我们旨在确定婴儿早期肠道中丁酸细菌的产生是否能预防儿童特应性疾病的发展。
我们使用鸟枪法宏基因组分析来确定丁酸发酵失调是否可以在人类婴儿中被识别，在他们发展成过敏疾病之前。
我们发现，后来在儿童时期发展成过敏敏感的婴儿的微生物组缺乏编码碳水化合物分解和丁酸盐产生关键酶的基因。
我们的发现支持在生命早期微生物碳水化合物代谢对预防过敏发展的重要性。
