Nguyen Tanya T, Risbud Rashmi D, Chambers Christina D, Thomas Jennifer D
VA San Diego Healthcare System , Mental Illness Research, Education, and Clinical Center (MIRECC), San Diego, California.
Department of Psychiatry , University of California, San Diego, California.
Alcohol Clin Exp Res. 2016 May;40(5):1075-82. doi: 10.1111/acer.13035. Epub 2016 Mar 25.
Nutrition is an important factor that affects brain development. Nutritional deficiencies can exacerbate alcohol's damaging effects. Conversely, nutritional supplementation can serve a protective role against alcohol damage and may prove to be a worthwhile intervention strategy. This study investigated dietary intake in school-aged children with heavy prenatal alcohol exposure to understand their nutritional status, compared to a national sample of typically developing children and Dietary Reference Intakes.
Dietary intake data were collected from children with confirmed histories of heavy prenatal alcohol exposure (5 to 10 years, n = 55) using the Automated Self-Administered 24-Hour Dietary Recall (ASA24). Observed nutrient levels were compared to the Dietary Reference Intakes to evaluate adequacy of nutrient intake as well as to national averages for same-aged children (What We Eat in America, NHANES 2007-2008).
Alcohol-exposed children exhibited poorer nutritional status compared to the typically developing NHANES sample, consuming lower levels of protein, omega-3 fatty acids, magnesium, potassium, zinc, vitamins C and K, niacin, and choline. Moreover, their diets did not meet Recommended Dietary Allowance or Adequate Intake for dietary fiber, potassium, vitamins E and K, omega-3 fatty acids, and choline.
The present findings are consistent with prior studies investigating nutritional intake in preschoolers with FASD, indicating that these children are vulnerable to nutritional inadequacies. Moreover, data suggest a specific profile of dietary intake in this population. As several nutrients are important for cognitive development, targeted interventions in clinical populations might be effective in boosting outcomes. Thus, further clinical investigation into the role of nutrition in improving cognitive outcomes is warranted.
营养是影响大脑发育的重要因素。营养缺乏会加剧酒精的破坏作用。相反,营养补充可以起到预防酒精损害的作用,可能被证明是一种值得采用的干预策略。本研究调查了产前酒精暴露量高的学龄儿童的饮食摄入情况,以了解他们的营养状况,并与全国发育正常儿童样本及膳食参考摄入量进行比较。
采用自动自填式24小时膳食回顾法(ASA24),收集了产前酒精暴露量高且情况得到确认的儿童(5至10岁,n = 55)的饮食摄入数据。将观察到的营养素水平与膳食参考摄入量进行比较,以评估营养素摄入的充足程度,并与同龄儿童的全国平均水平(2007 - 2008年美国国家健康与营养检查调查中的“我们吃什么”)进行比较。
与发育正常的美国国家健康与营养检查调查样本相比,产前酒精暴露儿童的营养状况较差,蛋白质、ω-3脂肪酸、镁、钾、锌、维生素C和K、烟酸以及胆碱的摄入量较低。此外,他们的饮食未达到膳食纤维、钾、维生素E和K、ω-3脂肪酸以及胆碱的推荐膳食摄入量或适宜摄入量。
本研究结果与之前关于胎儿酒精谱系障碍学龄前儿童营养摄入情况的研究一致,表明这些儿童容易出现营养不足。此外,数据显示了该人群特定的饮食摄入特征。由于几种营养素对认知发育很重要,针对临床人群的针对性干预可能有助于改善结果。因此,有必要进一步对营养在改善认知结果中的作用进行临床研究。