May Philip A, Hamrick Kari J, Corbin Karen D, Hasken Julie M, Marais Anna-Susan, Brooke Lesley E, Blankenship Jason, Hoyme H Eugene, Gossage J Phillip
University of North Carolina at Chapel Hill, Nutrition Research Institute, Gillings School of Global Public Health, USA; The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA), Albuquerque, USA.
Navigate Nutrition Consulting, PLLC, Seattle, USA.
Reprod Toxicol. 2014 Jul;46:31-9. doi: 10.1016/j.reprotox.2014.02.002. Epub 2014 Feb 22.
In this study, we describe the nutritional status of women from a South African community with very high rates of fetal alcohol spectrum disorders (FASD). Nutrient intake (24-h recall) of mothers of children with FASD was compared to mothers of normal controls. Nutrient adequacy was assessed using Dietary Reference Intakes (DRIs). More than 50% of all mothers were below the Estimated Average Requirement (EAR) for vitamins A, D, E, and C, thiamin, riboflavin, vitamin B6, folate, calcium, magnesium, iron, and zinc. Mean intakes were below the Adequate Intake (AI) for vitamin K, potassium, and choline. Mothers of children with FASD reported significantly lower intake of calcium, docosapentaenoic acid (DPA), riboflavin, and choline than controls. Lower intake of multiple key nutrients correlates significantly with heavy drinking. Poor diet quality and multiple nutritional inadequacies coupled with prenatal alcohol exposure may increase the risk for FASD in this population.
在本研究中,我们描述了来自南非一个胎儿酒精谱系障碍(FASD)发生率极高的社区的女性的营养状况。将患有FASD儿童的母亲的营养素摄入量(24小时回顾法)与正常对照儿童的母亲进行了比较。使用膳食参考摄入量(DRIs)评估营养素充足情况。超过50%的母亲的维生素A、D、E、C、硫胺素、核黄素、维生素B6、叶酸、钙、镁、铁和锌摄入量低于估计平均需求量(EAR)。平均摄入量低于维生素K、钾和胆碱的适宜摄入量(AI)。患有FASD儿童的母亲报告的钙、二十二碳五烯酸(DPA)、核黄素和胆碱摄入量明显低于对照组。多种关键营养素的低摄入量与大量饮酒显著相关。不良的饮食质量和多种营养不足,再加上产前酒精暴露,可能会增加该人群患FASD的风险。