Pagano Joseph S, Shackelford Julia
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.
Blood. 2016 Mar 24;127(12):1524-5. doi: 10.1182/blood-2016-01-689984.
In this issue of Blood, Bedekovics et al have demonstrated that a multifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in diffuse large B-cell lymphomas (DLBCLs), and that levels of this molecule are higher in germinal center (GC) B-cell DLBCL (GCB-DLBCL) compared with activated B-cell DLBCL (ABC-DLBCL) and predict poor outcomes.
在本期《血液》杂志中,贝德科维奇斯等人证明,泛素系统的多功能分子泛素C末端水解酶L1(UCH-L1)在弥漫性大B细胞淋巴瘤(DLBCL)中被诱导表达,并且与活化B细胞DLBCL(ABC-DLBCL)相比,该分子在生发中心(GC)B细胞DLBCL(GCB-DLBCL)中的水平更高,且预示着不良预后。