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可卡因依赖治疗的评估

Evaluation of treatment for cocaine dependence.

作者信息

O'Brien C P, Alterman A, Walter D, Childress A R, McLellan A T

机构信息

Addiction Research Center, University of Pennsylvania, Philadelphia.

出版信息

NIDA Res Monogr. 1989;95:78-84.

PMID:2701324
Abstract
  1. At the Philadelphia VA Medical Center, veterans applying for treatment of cocaine dependence were significantly different from applicants dependent on opiates or alcohol without cocaine. The cocaine dependent patients were almost all black and they were mostly employed. Few were involved in crime and, for most, this was the first course of substance abuse treatment. Their use of cocaine began within the past three years and they had relatively few psychiatric, medical, employment or family problems when compared with other applicants for substance abuse treatment. 2. Completion rate for a course of outpatient treatment for cocaine dependence varies from a low of 37% in the general Day Treatment Program to 76% in a special Behavioral Treatment Program and 78% among methadone patients receiving an additional medication for cocaine dependence. Completion of a 28 day course of inpatient treatment was 86% whether the patient selected inpatient care or was assigned to it on a random basis. 3. Those outpatients who remained in treatment generally did well and refrained from cocaine use even during the course of outpatient, either day hospital treatment or behavioral treatment. When both inpatients and outpatients were re-examined four months after beginning treatment, there was significant improvement on almost all ASI categories. Both drop-outs and completers were re-examined. Despite the significantly greater completion rate for the patients assigned to inpatient treatment, both groups showed equal levels of improvements at the 4-month follow up point. 4. These preliminary results from five different treatment populations suggest that cocaine dependent patients can be engaged in treatment and that significant improvement is possible.
摘要
  1. 在费城退伍军人医疗中心,申请治疗可卡因成瘾的退伍军人与申请治疗阿片类药物或酒精成瘾但不涉及可卡因成瘾的退伍军人有显著差异。可卡因成瘾患者几乎全是黑人,且大多有工作。很少有人涉及犯罪,而且对大多数人来说,这是他们首次接受药物滥用治疗。他们使用可卡因始于过去三年,与其他药物滥用治疗申请者相比,他们在精神、医疗、就业或家庭方面的问题相对较少。2. 可卡因成瘾门诊治疗课程的完成率各不相同,在一般日间治疗项目中低至37%,在特殊行为治疗项目中为76%,在接受可卡因成瘾附加药物治疗的美沙酮患者中为78%。无论患者是选择住院治疗还是被随机分配住院治疗,28天住院治疗课程的完成率均为86%。3. 那些继续接受治疗的门诊患者总体表现良好,即使在日间医院治疗或行为治疗的门诊治疗过程中也能戒除可卡因。在开始治疗四个月后对住院患者和门诊患者进行复查时,几乎所有成瘾严重程度指数(ASI)类别都有显著改善。对退出治疗者和完成治疗者都进行了复查。尽管被分配到住院治疗的患者完成率明显更高,但在4个月随访时两组的改善程度相当。4. 来自五个不同治疗人群的这些初步结果表明,可卡因成瘾患者可以参与治疗,并且有可能取得显著改善。

相似文献

1
Evaluation of treatment for cocaine dependence.可卡因依赖治疗的评估
NIDA Res Monogr. 1989;95:78-84.
2
Benefits of retention in methadone maintenance and chronic medical conditions as risk factors for premature death among older heroin addicts.老年海洛因成瘾者中,美沙酮维持治疗的留存益处及慢性疾病作为过早死亡的风险因素。
J Psychiatr Pract. 2009 May;15(3):227-34. doi: 10.1097/01.pra.0000351884.83377.e2.
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Desipramine treatment of cocaine abuse in methadone maintenance patients.地昔帕明治疗美沙酮维持治疗患者的可卡因滥用问题。
NIDA Res Monogr. 1989;95:322-3.
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Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial.去甲丙咪嗪治疗伴有抑郁症的可卡因依赖患者:一项安慰剂对照试验。
Drug Alcohol Depend. 2005 Nov 1;80(2):209-21. doi: 10.1016/j.drugalcdep.2005.03.026.
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DHEAS and POMS measures identify cocaine dependence treatment outcome.硫酸脱氢表雄酮(DHEAS)和情绪状态量表(POMS)测量可识别可卡因依赖治疗结果。
Psychoneuroendocrinology. 2005 Jan;30(1):18-28. doi: 10.1016/j.psyneuen.2004.04.006.
6
The effectiveness of telephone-based continuing care for alcohol and cocaine dependence: 24-month outcomes.基于电话的酒精和可卡因依赖持续护理的有效性:24个月的结果。
Arch Gen Psychiatry. 2005 Feb;62(2):199-207. doi: 10.1001/archpsyc.62.2.199.
7
Cocaine treatment outcome: cocaine use following inpatient, outpatient, and no treatment.可卡因治疗结果:住院治疗、门诊治疗及未治疗后的可卡因使用情况。
NIDA Res Monogr. 1986;67:271-7.
8
Pharmacological and behavioral treatments of cocaine dependence: controlled studies.可卡因依赖的药理学和行为治疗:对照研究。
J Clin Psychiatry. 1988 Feb;49 Suppl:17-22.
9
[Prospective study of favorable factors in follow-up of drug addicted patients--apropos of 257 patients of the Cassini Center in Paris].药物成瘾患者随访中有利因素的前瞻性研究——关于巴黎卡西尼中心的257例患者
Encephale. 2000 Nov-Dec;26(6):11-20.
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Rehabilitation of heroin and cocaine abusers managed in a Nigerian psychiatric hospital.尼日利亚一家精神病医院收治的海洛因和可卡因滥用者的康复情况。
East Afr Med J. 1998 Feb;75(2):107-12.

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