Mongelli Max, Lu Chuan, Reid Shannon, Stamatopoulos Nicole, Sankaralingam Kaantharuban, Casikar Ishwari, Hardy Nigel, Condous George
a Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney , Sydney , Australia , and.
b Department of Computer Science , Aberystwyth University , Wales , UK.
J Obstet Gynaecol. 2016 Aug;36(6):726-730. doi: 10.3109/01443615.2016.1148676. Epub 2016 Mar 25.
In this study, we tested the hypothesis that anomalous first trimester growth affects birth weight. Four hundred and fifteen women with viable singleton pregnancies at the primary transvaginal scan who had at least two crown rump length (CRL) and birth weight data were included. A linear mixed model was fitted to the Box-Cox transformed CRL values to evaluate the association between the GA and the embryonic growth. For multivariate analysis we included maternal age, height, weight, parity, number of miscarriages, vaginal bleeding, smoking, foetal gender, birth weight, small-for-gestation (SGA) and large-for gestation (LGA) categories at delivery. Smoking appeared to be significant for predicting the initial CRL from the beginning of the pregnancy (p value = 0.013). The SGA foetuses appeared to have slightly slower embryonic growth rates compared to non-SGA (p value = 0.045), after taking into account the effect of smoking on the initial CRL. None of the other variables including subsequent birth weight or LGA category have statistically significant effect on the first trimester embryonic growth curve when tested separately.
在本研究中，我们检验了孕早期异常生长会影响出生体重这一假设。纳入了415名单胎存活妊娠的女性，她们在初次经阴道超声检查时有至少两次头臀长（CRL）和出生体重数据。对经Box-Cox变换后的CRL值拟合线性混合模型，以评估孕周（GA）与胚胎生长之间的关联。多变量分析中，我们纳入了产妇年龄、身高、体重、产次、流产次数、阴道出血、吸烟情况、胎儿性别、出生体重、分娩时小于胎龄（SGA）和大于胎龄（LGA）类别。吸烟对于从妊娠开始预测初始CRL似乎具有显著意义（p值 = 0.013）。在考虑吸烟对初始CRL的影响后，SGA胎儿的胚胎生长速度似乎比非SGA胎儿略慢（p值 = 0.045）。单独检验时，包括后续出生体重或LGA类别在内的其他变量对孕早期胚胎生长曲线均无统计学显著影响。
