Love Richard R, Love Susan M
The Amader Gram Cancer Care and Research Center, Rampal, Bangladesh.
, 2708 Columbia Road, Madison, WI, 53705, USA.
Breast Cancer Res Treat. 2016 Apr;156(3):411-413. doi: 10.1007/s10549-016-3762-7. Epub 2016 Mar 24.
Over the last 25 years, there has been a growing body of basic science, modeling, and clinical data suggesting that the peri-operative period in the treatment of primary breast cancer is dynamic and can be manipulated to improve long-term outcomes. Clinical data have demonstrated early peaks of hazards for recurrence and emphasized the relationship of these to peri-operative events. More recently, clinical trial data with surgical oophorectomy at different times in the menstrual cycle, peri-operative progesterone, and anti-inflammatory drugs suggest that interventional studies are particularly well justified, given the increasing recognition of the costs both financially and clinically of current systemic regimens.
在过去25年中，越来越多的基础科学、模型和临床数据表明，原发性乳腺癌治疗的围手术期是动态的，可以通过调整来改善长期预后。临床数据显示了复发风险的早期高峰，并强调了这些风险与围手术期事件的关系。最近，关于在月经周期不同时间进行手术去势、围手术期使用孕酮和抗炎药物的临床试验数据表明，鉴于人们越来越认识到当前全身治疗方案在经济和临床方面的成本，干预性研究是非常合理的。
