Swain S M, Lippman M E
Breast Evaluation Clinic, Georgetown U Medical Center.
Oncology (Williston Park). 1989 Jan;3(1):21-8; discussion 28-30, 34.
For patients with locally advanced breast cancer, mastectomy and/or radiation therapy achieve poor survival rates. However, the addition of cytotoxic chemotherapy optimizes outcome by treating micrometastases that are present at diagnosis. Current recommendations specify maximum doses of systemic therapy, preferably a doxorubicin-containing regimen, prior to local therapy with radiation and/or surgery. The authors review randomized studies of chemotherapy, radiation, and various combinations given pre- or postoperatively, as well as nonrandomized studies using combination chemotherapy regimens. They also discuss the possible future use of high-dose chemotherapy with autologous bone marrow rescue and the potential of manipulating growth factors which regulate breast cancer.
对于局部晚期乳腺癌患者，乳房切除术和/或放射治疗的生存率较低。然而，添加细胞毒性化疗通过治疗诊断时已存在的微转移灶来优化治疗结果。目前的建议明确了在进行放射和/或手术局部治疗之前全身治疗的最大剂量，最好是含阿霉素的方案。作者回顾了术前或术后给予化疗、放疗及各种联合治疗的随机研究，以及使用联合化疗方案的非随机研究。他们还讨论了未来使用高剂量化疗联合自体骨髓挽救的可能性以及调控乳腺癌生长因子的潜力。
