Tambo Amos, Roshan Mohsin H K, Pace Nikolai P
Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta- Msida, Malta.
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Biomedical Sciences Building, Msida, Malta.
Open Cardiovasc Med J. 2016 Jan 15;10:1-10. doi: 10.2174/1874192401610010001. eCollection 2016.
Cardiovascular disease [CVD] is a leading cause of mortality accounting for a global incidence of over 31%. Atherosclerosis is the primary pathophysiology underpinning most types of CVD. Historically, modifiable and non-modifiable risk factors were suggested to precipitate CVD. Recently, epidemiological studies have identified emerging risk factors including hypotestosteronaemia, which have been associated with CVD. Previously considered in the realms of reproductive biology, testosterone is now believed to play a critical role in the cardiovascular system in health and disease. The actions of testosterone as they relate to the cardiac vasculature and its implication in cardiovascular pathology is reviewed.
心血管疾病（CVD）是导致死亡的主要原因，在全球发病率超过31%。动脉粥样硬化是大多数类型CVD的主要病理生理学基础。从历史上看，可改变和不可改变的风险因素被认为会引发CVD。最近，流行病学研究已经确定了包括低睾酮血症在内的新出现的风险因素，这些因素与CVD有关。睾酮以前被认为属于生殖生物学领域，现在人们认为它在心血管系统的健康和疾病中起着关键作用。本文综述了睾酮与心脏血管系统相关的作用及其在心血管病理学中的意义。
