Haddad Joseph, Shammaa Dina, Abbas Fatmeh, Mahfouz Rami A R
Department of Pathology & Laboratory Medicine, AUBMC, Lebanon.
Meta Gene. 2016 Jan 21;8:11-3. doi: 10.1016/j.mgene.2016.01.004. eCollection 2016 Jun.
HLA-DPA1 is an important marker in bone marrow and organ transplantation and a highly emerging screening parameter in histocompatibility laboratories. Being highly polymorphic, it has another significant value in detecting population origins and migrations. This is the first study to assess DPA1 allele frequencies in an Arab population.
The HLA DPA1 alleles were identified using the One-Lambda assays on a Luminex reverse SSO DNA typing system. Our study included 101 individuals coming from different Lebanese geographical areas representing the different communities and religious sects of the country.
We compared the results of this study to 16 different populations and found very interesting similarities and differences between Lebanese people and individuals of European ancestry.
This study is the first to describe the different allelic frequencies of HLA-DPA1 in the Lebanese population and will serve as a template that can be later used for disease association studies both at the level of the country and internationally.
HLA - DPA1是骨髓和器官移植中的一个重要标志物，也是组织相容性实验室中一个新兴的高度重要的筛查参数。由于其具有高度多态性，在检测人群起源和迁徙方面具有另一个重要价值。这是第一项评估阿拉伯人群中DPA1等位基因频率的研究。
在Luminex反向SSO DNA分型系统上使用One - Lambda检测法鉴定HLA DPA1等位基因。我们的研究纳入了101名来自黎巴嫩不同地理区域的个体，这些个体代表了该国不同的社区和宗教派别。
我们将本研究结果与16个不同人群进行了比较，发现黎巴嫩人与欧洲血统个体之间存在非常有趣的异同。
本研究首次描述了黎巴嫩人群中HLA - DPA1的不同等位基因频率，并将作为一个模板，供该国及国际层面后续进行疾病关联研究使用。
