Krasnow S H
Oncology Section, VA Medical Center, Washington, DC.
Oncology (Williston Park). 1989 Aug;3(8 Suppl):5-10.
Research in the control of chemotherapy-induced nausea and vomiting is a relatively new endeavor. Accurate assessment of clinical trial results assumes a sound study design, control for known variables, clear definitions, and reproducible assessment criteria. In most of these areas, antiemetic trials still lag behind cancer treatment trials. This paper reviews 44 antiemetic trials and discusses the state of the art in antiemetic research methodology, examining how a representative sample of investigators have addressed patient selection criteria, study design, and assessment parameters. Comparisons with the chemotherapy literature suggest approaches to improve the antiemetic literature and optimize our use of the data derived from it.
化疗引起的恶心和呕吐控制方面的研究是一项相对较新的工作。对临床试验结果的准确评估需要合理的研究设计、对已知变量的控制、明确的定义以及可重复的评估标准。在这些领域的大多数方面，止吐试验仍落后于癌症治疗试验。本文回顾了44项止吐试验，并讨论了止吐研究方法的现状，考察了一组有代表性的研究者如何确定患者选择标准、研究设计和评估参数。与化疗文献的比较提出了改进止吐文献并优化我们对其中所获数据利用的方法。
