Llorens Franc, Schmitz Matthias, Ferrer Isidro, Zerr Inga
Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Prog Neurobiol. 2016 Mar-May;138-140:36-53. doi: 10.1016/j.pneurobio.2016.03.003. Epub 2016 Mar 22.
Neurodegenerative diseases with abnormal protein aggregates such as Alzheimer's disease, tauopathies, synucleinopathies, and prionopathies, together with vascular encephalopathies, are cause of cognitive impairment and dementia. Identification of reliable biomarkers in biological fluids, particularly in the cerebrospinal fluid (CSF), is of extreme importance in optimizing the precise early clinical diagnosis of distinct entities and predicting the outcome in particular settings. In addition, the study of CSF biomarkers is useful to identify and monitor the underlying pathological processes developing in the central nervous system of affected individuals. Evidence suggests that levels of key CSF molecules correlate, in some circumstances, with prediction, disease progression, and severity of cognitive decline. Correlation of CSF markers and underlying pathological molecular substrates in brain is an exciting field for further study. However, while some dementias such as Creutzfeldt-Jakob disease have accurate CSF biomarkers, other disease types such as dementia with Lewy bodies, vascular dementia, and frontotemporal dementia lack reliable biomarkers for their specific clinical diagnosis.
伴有异常蛋白质聚集体的神经退行性疾病，如阿尔茨海默病、tau蛋白病、α-突触核蛋白病和朊病毒病，与血管性脑病一起，是认知障碍和痴呆的病因。在生物体液中，尤其是脑脊液（CSF）中鉴定可靠的生物标志物，对于优化不同疾病实体的精确早期临床诊断以及预测特定情况下的结果极为重要。此外，脑脊液生物标志物的研究有助于识别和监测受影响个体中枢神经系统中正在发生的潜在病理过程。有证据表明，在某些情况下，关键脑脊液分子的水平与预测、疾病进展和认知衰退的严重程度相关。脑脊液标志物与大脑中潜在病理分子底物的相关性是一个值得进一步研究的令人兴奋的领域。然而，虽然一些痴呆症，如克雅氏病，有准确的脑脊液生物标志物，但其他疾病类型，如路易体痴呆、血管性痴呆和额颞叶痴呆，缺乏用于其特定临床诊断的可靠生物标志物。
