陷入Wnt风暴：造血过程中Wnt信号传导的复杂性

Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis.

作者信息

Staal Frank J T, Chhatta Amiet, Mikkers Harald

机构信息

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Exp Hematol. 2016 Jun;44(6):451-7. doi: 10.1016/j.exphem.2016.03.004. Epub 2016 Mar 23.

DOI:10.1016/j.exphem.2016.03.004

PMID:27016274

Abstract

The Wnt signaling pathway is an evolutionary conserved pathway that is involved in the development of almost every organ system in the body and provides self-renewal signals for most, if not all, adult stem cell systems. In recent years, this pathway has been studied by various research groups working on hematopoietic stem cells, resulting in contradicting conclusions. Here, we discuss and interpret the results of these studies and propose that Wnt dosage, the source of hematopoietic stem cells, and interactions with other pathways explain these disparate results.

摘要

Wnt信号通路是一条进化上保守的通路，参与身体几乎每个器官系统的发育，并为大多数（如果不是全部）成体干细胞系统提供自我更新信号。近年来，多个研究小组对造血干细胞进行了研究，得出了相互矛盾的结论。在此，我们讨论并解读这些研究结果，并提出Wnt剂量、造血干细胞来源以及与其他通路的相互作用可以解释这些不同的结果。