Char D H
Department of Ophthalmology, Francis I. Proctor Foundation, U of California, San Francisco.
Oncology (Williston Park). 1989 Sep;3(9):113-21; discussion 122, 124, 127-8.
Treatment options for uveal melanomas include radiation using brachytherapy or charged particle beams, photocoagulation, laser, eye wall resection, and enucleation. Goals of therapy are to avoid metastatic disease and, if possible, retain both the eye and good vision. Obviously, treatment options are controversial. Questions remain regarding enucleation vs other forms of therapy, and the author presents guidelines to consider in structuring clinical trials to answer them. They include: Will entry in a trial provide optimum clinical care for the patient? Does the trial ask a valid, important question? Does the trial produce significant answers in a short enough time so that the information is relevant?
葡萄膜黑色素瘤的治疗选择包括近距离放射治疗或带电粒子束放疗、光凝、激光、眼球壁切除术和眼球摘除术。治疗的目标是避免转移性疾病，并且如果可能的话，保留眼球和良好的视力。显然，治疗选择存在争议。关于眼球摘除术与其他治疗形式的问题仍然存在，并且作者提出了在构建临床试验以回答这些问题时需要考虑的指导原则。它们包括：参加试验是否能为患者提供最佳临床护理？试验提出的问题是否有效、重要？试验能否在足够短的时间内得出有意义的答案，以便信息具有相关性？
