Nishiyama Misuzu, Togashi Hideaki, Iida Takehiko
Masui. 2016 Feb;65(2):125-30.
We compared three combined spinal-epidural anesthesia (CSEA) techniques for cesarean delivery. Hypotension, nausea and vomiting are main problems produced by coonventional intrathecal doses. These problems were our secondary observations. Our primary observations were motor recovery and intraoperative pain.
Sixty patients were randomly allocated to one of the 3 groups (n = 20 per group). Group B (conventional dose): received intrathecally 0.5% hyperbaric bupivacaine (10 mg; < 160 cm in height 11 mg ; ≥ 160 cm in height) and epidural catheter at T12-L1. Group F (low-dose and addition of fentanyl) : received intrathecally 0.5% hyperbaric bupivacaine (70% of group B) with fentanyl 20 mg and epidural catheter at T12-L1. Group E (low-dose and epidural volume extension : EVE) : received intrathecally 0.5% hyperbaric bupivacaine (70% of group B) and epidural catheter at L3-4, through which 10 ml saline was injected 3 minutes after intrathecal injection.
Group F and E demonstrated faster motor recovery than group B. More patients in group E than those in group B and F complained of intraoperative pain. There was no incidence of hypotension, nausea and vomiting.
Group F and group E demonstrated similar fast motor recovery, but the former caused less intraoperative pain than the latter. Because this is an observational study, comparison of techniques such as addition of fentanyl, EVE, needs a compatative study.
我们比较了三种用于剖宫产的腰麻-硬膜外联合麻醉(CSEA)技术。低血压、恶心和呕吐是传统鞘内给药剂量产生的主要问题。这些问题是我们的次要观察指标。我们的主要观察指标是运动恢复和术中疼痛。
60例患者随机分为3组之一(每组n = 20)。B组(传统剂量组):鞘内注射0.5% 重比重布比卡因(身高< 160 cm者10 mg,身高≥ 160 cm者11 mg),并于T12-L1置硬膜外导管。F组(低剂量加芬太尼组):鞘内注射0.5% 重比重布比卡因(B组剂量的70%)加芬太尼20 mg,并于T12-L1置硬膜外导管。E组(低剂量加硬膜外容量扩展组:EVE):鞘内注射0.5% 重比重布比卡因(B组剂量的70%),并于L3-4置硬膜外导管,鞘内注射后3分钟通过该导管注入10 ml生理盐水。
F组和E组的运动恢复比B组更快。E组中抱怨术中疼痛的患者比B组和F组更多。未发生低血压、恶心和呕吐。
F组和E组表现出相似的快速运动恢复,但前者引起的术中疼痛比后者少。由于这是一项观察性研究,比较诸如添加芬太尼、EVE等技术需要进行对照研究。