Matikainen Sampsa, Jokiranta Sakari, Eklund Kari K
Duodecim. 2016;132(4):349-54.
Rheumatoid arthritis, inflammatory bowel diseases and psoriasis are examples of immune-mediated inflammatory diseases. They involve activation of a partly similar cytokine network that has an essential role in the disease pathogenesis. Biological drugs have been developed for the inhibition of single cytokines, and good therapeutic responses have been achieved by using them. For instance, TNF blockers are used in the treatment of several inflammatory diseases. The use of the blockers of certain other cytokines is more limited. Other important target molecules include certain interleukins. New bispecific antibodies enabling inhibition of the action of two distinct cytokines are currently undergoing clinical studies.
类风湿性关节炎、炎症性肠病和银屑病是免疫介导的炎症性疾病的例子。它们涉及部分相似的细胞因子网络的激活，该网络在疾病发病机制中起重要作用。已经开发出用于抑制单一细胞因子的生物药物，并且使用它们已经取得了良好的治疗效果。例如，肿瘤坏死因子阻滞剂用于治疗几种炎症性疾病。某些其他细胞因子阻滞剂的使用则更为有限。其他重要的靶分子包括某些白细胞介素。目前，能够抑制两种不同细胞因子作用的新型双特异性抗体正在进行临床研究。
