两例成功根除囊性纤维化患儿中新分离出的洋葱伯克霍尔德菌复合体的病例报告。
Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis.
作者信息
Kitt H, Lenney W, Gilchrist F J
机构信息
Royal Stoke University Hospital, Stoke on Trent, ST4 6QG, UK.
Academic Department of Child Health, Royal Stoke University Hospital, Newcastle Road, Stoke on Trent, ST4 6QG, UK.
出版信息
BMC Pharmacol Toxicol. 2016 Mar 28;17:14. doi: 10.1186/s40360-016-0054-0.
BACKGROUND
Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity of information to guide treatment. We report the successful eradication of new isolates of BCC in two children with CF.
CASE PRESENTATION
Burkholderia cepacia was successfully eradicated in a 14 year old boy with CF and Burkholderia gladioli was successfully eradicated in a six year old girl with CF. In both children two weeks of intravenous (IV) tobramycin, ceftazidime and temocillin were used followed by three months of inhaled tobramycin. Bronchoalveolar lavage samples taken during flexible bronchoscopy were used prior to treatment to exclude spontaneous clearance as well as after treatment to confirm eradication.
CONCLUSIONS
New isolates of BCC can be successfully eradicated in children with CF. More research is urgently required in this area to identify the best treatment regimen for BCC eradication.
背景
洋葱伯克霍尔德菌复合体（BCC）的慢性感染对囊性纤维化（CF）患者的发病率和死亡率有不利影响。因此，尝试根除新分离株是合理的，但目前缺乏指导治疗的信息。我们报告了两例CF患儿新分离的BCC被成功根除的病例。
病例报告
一名14岁CF男孩的洋葱伯克霍尔德菌被成功根除，一名6岁CF女孩的唐菖蒲伯克霍尔德菌被成功根除。两名患儿均接受了两周的静脉注射（IV）妥布霉素、头孢他啶和替莫西林治疗，随后进行了三个月的吸入性妥布霉素治疗。在治疗前，通过柔性支气管镜检查采集支气管肺泡灌洗样本以排除自发清除情况，并在治疗后用于确认根除。
结论
CF患儿新分离的BCC可以被成功根除。该领域迫切需要更多研究以确定根除BCC的最佳治疗方案。
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