Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, 1900 University Blvd, THT 422, Birmingham, AL, 35294, USA.
Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, AL, USA.
BMC Pulm Med. 2018 Feb 14;18(1):35. doi: 10.1186/s12890-018-0594-8.
Infection with Burkholderia cepacia complex (Bcc) results in a heterogeneous clinical course ranging from asymptomatic colonization of the airways to fulminant respiratory failure in patients with cystic fibrosis (CF). Early eradication of Pseudomonas aeruginosa improves clinical outcomes. The efficacy and clinical outcomes following implementation of an eradication protocol for Bcc are less well understood.
We developed and implemented a single center Bcc eradication protocol that included an intensive combination of intravenous, inhaled, and oral antibiotic therapies based on in vitro sensitivities. We conducted a retrospective cohort analysis of clinical outcomes compared to patients with chronic Bcc infection.
Six patients were identified as having a newly acquired Bcc colonization and were placed on the eradication protocol. Sequential sputum samples after completion of the protocol demonstrated sustained clearance of Bcc in all patients. Lung function and nutritional status remained stable in the year following eradication.
Clearance of Bcc from sputum cultures using a standardized protocol was successful at one year and was associated with clinical stability.
洋葱伯克霍尔德菌复合群（Bcc）感染可导致从无症状的气道定植到囊性纤维化（CF）患者暴发性呼吸衰竭等不同的临床病程。早期清除铜绿假单胞菌可改善临床结局。实施 Bcc 清除方案后的疗效和临床结局了解较少。
我们制定并实施了一项单中心 Bcc 清除方案，该方案基于体外药敏试验，包括静脉、吸入和口服抗生素的强化联合治疗。我们对临床结局进行了回顾性队列分析，并与慢性 Bcc 感染患者进行了比较。
确定了 6 例新发生的 Bcc 定植患者，并采用清除方案进行治疗。方案完成后连续的痰标本检测显示所有患者均持续清除 Bcc。清除后一年，肺功能和营养状况保持稳定。
使用标准化方案从痰培养中清除 Bcc 在一年时是成功的，且与临床稳定性相关。
