以胶原蛋白覆盖的“达洛普”网作为硬脑膜替代物的实验评估。

Experimental evaluation of the net "Dallop" covered with collagen as the dural substitute.

作者信息

Harat M, Radek A, Koktysz R, Kulig A

机构信息

Department of Neurosurgery, Military Medical Academy, Lódź.

出版信息

Zentralbl Neurochir. 1989;50(3-4):145-8.

PMID:2701911

Abstract

Evaluation of the usefulness of the net "Dallop" produced by Tricomed Lódź covered with collagen to the dural defects reparation was analysed. This new original product of Lódź Technical University was compared with widely used in neurosurgery "Zenoderm" produced by Ethicon and "Duratexol" produced by Czechoslovakia. The trial was conducted on 38 rabbits: 4 as a control group (just an original dura sutured after incision with Mersilk Ethicon sutures), 19 with implanted the net "Dallop" covered with collagen, 11 with the "Zenoderm" and 4 with the "Duratexol". Animals were sacrificed after 3, 14, 30 or 90 days after surgery. There were no significant differences between all analysed groups in clinical, macroscopical and morphological investigations. No negative local reactions in histopathological evaluation of the net "Dallop" covered with collagen were observed. The results of our investigations show that the net "Dallop" covered with collagen seems to be the "Zenoderm" and the "Duratexol" dural substitute.

摘要

分析了罗兹的Tricomed公司生产的覆盖胶原蛋白的“Dallop”网对硬脑膜缺损修复的有效性。罗兹工业大学的这款新原创产品与Ethicon公司在神经外科广泛使用的“Zenoderm”以及捷克斯洛伐克生产的“Duratexol”进行了比较。该试验在38只兔子身上进行：4只作为对照组（仅用Ethicon公司的Mersilk缝线在切开后缝合原始硬脑膜），19只植入覆盖胶原蛋白的“Dallop”网，11只植入“Zenoderm”，4只植入“Duratexol”。术后3、14、30或90天处死动物。在临床、宏观和形态学研究中，所有分析组之间均无显著差异。在对覆盖胶原蛋白的“Dallop”网的组织病理学评估中未观察到负面局部反应。我们的研究结果表明，覆盖胶原蛋白的“Dallop”网似乎是“Zenoderm”和“Duratexol”的硬脑膜替代物。