将NEK2作为一种有前景的癌症治疗方法进行靶向治疗。
Targeting NEK2 as a promising therapeutic approach for cancer treatment.
作者信息
Fang Yanfen, Zhang Xiongwen
机构信息
a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, College of Chemistry and Molecular Engineering, East China Normal University , Shanghai , China.
出版信息
Cell Cycle. 2016;15(7):895-907. doi: 10.1080/15384101.2016.1152430.
Abstract
Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating mitotic processes, including centrosome duplication and separation, microtubule stabilization, kinetochore attachment and spindle assembly checkpoint. NEK2 is aberrantly overexpressed in a wide variety of human cancers and has been implicated in various aspects of malignant transformation, including tumorigenesis, drug resistance and tumor progression. The close relationship between NEK2 and cancer has made it an attractive target for anticancer therapeutic development; however, the mechanisms of how NEK2 coordinates altered signaling to malignant transformation remains unclear. In this paper, we discuss the functional roles of NEK2 in cancer development; highlight some of the significant NEK2 signaling in cancer, and summarize recent advances in the development of NEK2 inhibitors.
摘要
有丝分裂相关激酶2（NEK2）在调控有丝分裂过程中发挥关键作用，包括中心体复制与分离、微管稳定、动粒附着以及纺锤体组装检查点。NEK2在多种人类癌症中异常过表达，并与恶性转化的各个方面相关，包括肿瘤发生、耐药性和肿瘤进展。NEK2与癌症之间的密切关系使其成为抗癌治疗开发的一个有吸引力的靶点；然而，NEK2如何协调信号改变以促进恶性转化的机制仍不清楚。在本文中，我们讨论了NEK2在癌症发展中的功能作用；强调了癌症中一些重要的NEK2信号，并总结了NEK2抑制剂开发的最新进展。
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Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer.NIMA相关激酶2的过表达与前列腺癌的进展及不良预后相关。
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