Han D
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1989;24(2):66-9, 126.
The purpose of the present study was to investigate the sensitivity of compound action potential (CAP) tuning curves to changes of the cochlear status in guinea pigs after explosion and their ability to reflect specific histological variations. The results were as follows: 1. The CAP tuning curves were abnormally broad and the Q 10 dB values were reduced by a factor of 1 after explosion, indicating wider tuning. 2. The degree of broadening of the CAP tuning curves seemed to increase as the hair cell loss increased. 3. After explosion, the tip of the tuning curve shifted to frequencies significantly higher or lower than that of the signal, it might be related to the location of hair cell loss in the cochlea. 4. In animals for which damage was restricted to only three rows of outer hair cells, changes of the CAP tuning curves were observed. It provides further evidence that the tuning properties of cochlear nerve fibers are dependent upon the integrity of the outer hair cells even though the great majority of fibers innervate inner hair cells only.
本研究的目的是探讨爆震后豚鼠复合动作电位（CAP）调谐曲线对耳蜗状态变化的敏感性及其反映特定组织学变化的能力。结果如下：1. 爆震后CAP调谐曲线异常增宽，Q10dB值降低了1倍，表明调谐变宽。2. CAP调谐曲线的增宽程度似乎随着毛细胞损失的增加而增加。3. 爆震后，调谐曲线的尖端移至明显高于或低于信号频率的频率，这可能与耳蜗中毛细胞损失的位置有关。4. 在仅外毛细胞三排受损的动物中，观察到了CAP调谐曲线的变化。这进一步证明，尽管绝大多数神经纤维仅支配内毛细胞，但耳蜗神经纤维的调谐特性仍依赖于外毛细胞的完整性。
