Aalbers A M, Aarts M J, Krol A D G, Marijnen C A M, Posthuma E F M
Department of Haematology, Reinier de Graaf Group, Delft, the Netherlands.
Neth J Med. 2016 Mar;74(3):122-9.
Chronic lymphocytic leukaemia (CLL) is a common haematological malignancy that mainly occurs in the elderly population. Patients frequently have comorbidities compromising the use of old and new systemic therapies.
We report the prevalence of comorbidities in patients with CLL as present in the southern region of the Netherlands Cancer Registry. Comorbid conditions were present in 67% of the male and 63% of the female patients, and became more common with increasing age. Furthermore, we describe the beneficial local and abscopal effects of splenic irradiation in four patients with CLL who were not suitable for systemic chemoimmunotherapy because of severe comorbidities, or who were unwilling to undergo systemic therapy.
Our results show that, although an old tool, splenic irradiation should not be forgotten as a potentially effective palliative treatment option in frail patients with symptomatic CLL.
慢性淋巴细胞白血病（CLL）是一种常见的血液系统恶性肿瘤，主要发生于老年人群。患者常伴有合并症，这限制了新旧全身治疗方法的应用。
我们报告了荷兰癌症登记处南部地区CLL患者合并症的患病率。67%的男性患者和63%的女性患者存在合并症，且随着年龄增长合并症更为常见。此外，我们描述了脾照射对4例CLL患者的有益局部和远隔效应，这些患者因严重合并症不适合全身化学免疫治疗，或不愿接受全身治疗。
我们的结果表明，尽管脾照射是一种古老的治疗手段，但在有症状的体弱CLL患者中，作为一种潜在有效的姑息治疗选择，不应被遗忘。
