Kakurina G V, Kondakova I V, Cheremisina O V, Shishkin D A, Choinzonov E L
Tomsk Cancer Research Institute, Tomsk, Russia.
Bull Exp Biol Med. 2016 Mar;160(5):695-7. doi: 10.1007/s10517-016-3252-2. Epub 2016 Mar 29.
We compared the content of adenylyl cyclase-associated protein 1 (CAP1) in the blood and tissues of patients with head and neck squamous cell carcinomas (with and without regional metastases), patients with chronic inflammatory diseases aggravated by laryngeal and laryngopharyngeal dysplasia, and healthy individuals. The data suggest that serum CAP1 concentration correlated with the depth of primary tumor invasion and the presence of regional metastases. In cancer patients, the serum level of CAP1 was lower than in patients with laryngeal and laryngopharyngeal dysplasia, which can be of importance for differential and timely diagnostics of malignant tumors.
我们比较了头颈部鳞状细胞癌患者（有或无区域转移）、因喉及喉咽发育异常加重的慢性炎症性疾病患者以及健康个体血液和组织中腺苷酸环化酶相关蛋白1（CAP1）的含量。数据表明，血清CAP1浓度与原发肿瘤浸润深度及区域转移的存在相关。在癌症患者中，CAP1的血清水平低于喉及喉咽发育异常患者，这对于恶性肿瘤的鉴别和及时诊断可能具有重要意义。
