5-氟尿嘧啶在模型实验中对胸苷磷酸化酶活性的影响。
Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment.
作者信息
Stashkevich M A, Khomutov E V, Dumanskii Yu V, Matvienko A G, Zinkovich I I
机构信息
Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine.
出版信息
Bull Exp Biol Med. 2016 Mar;160(5):646-8. doi: 10.1007/s10517-016-3239-z. Epub 2016 Mar 29.
Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
在腹腔一次性注射5-氟尿嘧啶后1、3、6、12和24小时，研究了大鼠肝脏中胸苷磷酸化酶活性的变化。通过高效液相色谱法测量酶活性。在给予5-氟尿嘧啶3小时后观察到酶活性下降了2倍，并持续了12小时。在选择化疗方案时应考虑这种细胞抑制剂的额外作用。
Zotero 插件