Clinical Research Center, Fukuoka National Hospital, Fukuoka, Japan.
Second Department of Internal Medicine, School of Medicine, Nagasaki University, Nagasaki, Japan.
J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):505-11. doi: 10.1016/j.jaip.2016.02.001. Epub 2016 Mar 25.
Our previous study on lung sound analysis (LSA) revealed that the expiration-to-inspiration sound power ratio in a low-frequency range (E/I LF) was increased in patients with bronchial asthma, even when they have no wheezes.
We also monitored the expiration-to-inspiration sound power ratio in a mid-frequency range (E/I MF) and the mid- to low-frequency sound power ratio for inspiration and expiration (ie, I MF/LF and E MF/LF, respectively) using a new software program to examine which parameter is most suitable as an index of airway inflammation in patients with asthma.
A study was conducted in 31 patients with mild-to-moderate bronchial asthma to examine potential correlations of LSA parameters (E/I LF, E/I MF, I MF/LF, and E MF/LF) with spirogram parameters, airway hyperresponsiveness (PC20), fractional exhaled nitric oxide (NO), and sputum eosinophils.
E/I LF was significantly correlated with airway narrowing (forced expiratory volume in 1 second [FEV1.0]/forced vital capacity [FVC]%: r = -0.50, maximal expiratory flow at 50% [V50],%pred: r = -0.50) and peripheral airway inflammation (alveolar NO: r = 0.36, eosinophils in peripheral sputum: r = 0.41). E/I MF was significantly correlated with airway narrowing (FEV1.0/FVC%: r = -0.46, V50,%pred: r = -0.49), airway inflammation (bronchial NO: r = 0.43, alveolar NO: r = 0.47, eosinophils in peripheral sputum: r = 0.50), and airway hyperresponsiveness (logPC20: r = -0.49). E MF/LF was significantly correlated with airway inflammation (NO: r = 0.36, eosinophils in sputum: r = 0.40) and airway hyperresponsiveness (logPC20: r = -0.40). I MF/LF was not significantly correlated with any parameters.
Among the 4 LSA parameters investigated, E/I MF demonstrated the highest correlation with airway inflammation, and also with bronchial hyperresponsiveness.
我们之前的肺部声音分析（LSA）研究表明，支气管哮喘患者的低频呼气与吸气声能比（E/I LF）增加，即使他们没有喘息。
我们还使用新的软件程序监测了中频频域的呼气与吸气声能比（E/I MF）以及吸气和呼气的中低频声能比（即 I MF/LF 和 E MF/LF），以检查哪种参数最适合作为哮喘患者气道炎症的指标。
对 31 名轻中度支气管哮喘患者进行了一项研究，以检查 LSA 参数（E/I LF、E/I MF、I MF/LF 和 E MF/LF）与肺活量测定参数、气道高反应性（PC20）、呼气一氧化氮分数（NO）和痰中嗜酸性粒细胞之间的潜在相关性。
E/I LF 与气道狭窄（1 秒用力呼气量[FEV1.0]/用力肺活量[FVC]%：r = -0.50，50%最大呼气流量[V50]，%预测值：r = -0.50）和周围气道炎症（肺泡 NO：r = 0.36，外周痰中嗜酸性粒细胞：r = 0.41）显著相关。E/I MF 与气道狭窄（FEV1.0/FVC%：r = -0.46，V50，%预测值：r = -0.49）、气道炎症（支气管 NO：r = 0.43，肺泡 NO：r = 0.47，外周痰中嗜酸性粒细胞：r = 0.50）和气道高反应性（logPC20：r = -0.49）显著相关。E MF/LF 与气道炎症（NO：r = 0.36，痰中嗜酸性粒细胞：r = 0.40）和气道高反应性（logPC20：r = -0.40）显著相关。I MF/LF 与任何参数均无显著相关性。
在所研究的 4 个 LSA 参数中，E/I MF 与气道炎症相关性最高，与支气管高反应性也相关性最高。
