Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Cytokine Growth Factor Rev. 2016 Aug;30:103-11. doi: 10.1016/j.cytogfr.2016.03.007. Epub 2016 Mar 18.
More than 15% of the global cancer burden is attributable to infectious agents. Pathogens that cause persistent infections are strongly associated with cancer, inflammation being a major component of the chronic infections as revealed by basic, clinical and epidemiological studies. Persistent infection and viral oncoproteins induce specific cellular pathways modifications that promote tumorigenesis. Deregulated and continuous immune response leads to severe tissue and systemic damage, impaired tumor surveillance and consequent carcinogenesis promotion by selecting for metastatic and therapeutically resistant tumor phenotypes. In this review, the role of inflammatory microenvironment in the HPV-induced carcinogenesis is addressed, with a specific focus on the involvement of the immune molecules and microRNAs as well as their delivery through the microvesicle cargo.
全球癌症负担的 15%以上归因于感染因子。病原体引起的持续性感染与癌症密切相关，基础、临床和流行病学研究表明，慢性感染的一个主要组成部分是炎症。持续性感染和病毒癌蛋白诱导特定的细胞途径改变，促进肿瘤发生。失调和持续的免疫反应导致严重的组织和全身损伤，通过选择转移和治疗耐药的肿瘤表型，损害肿瘤监测并随后促进癌变。在这篇综述中，探讨了炎症微环境在 HPV 诱导的致癌作用中的作用，特别关注免疫分子和 microRNAs 的参与，以及它们通过微泡货物的递送来实现。
