Kuczyńska-Sicińska J, Wójcicka-Jagodzińska J, Czajkowski K, Smolarczyk R, Bentyn K
Ginekol Pol. 1989 Oct-Dec;60(10-12):465-9.
The studied group comprised 47 women in the 3rd trimester of pregnancy (29-40 weeks), including 17 with type I diabetes (study group) and 30 healthy women (control group). In the study group in one case diabetes was diagnosed during pregnancy and treated with diet only, in the remaining 16 pregnant women the mean diabetes duration was 6.2 years and the mean daily insulin dose was 70 u. According to White's classification one patient was in class A, 10 in class B and 6 in class C. In all cases renal function was normal, with normal blood values of creatinine, urea, electrolytes, uric acid, protein and acid-base equilibrium. Endogenous creatinine clearance was also normal. The studied biochemical parameters of renal tubular function included: 1) deamination of amino acids--with measurement of ammonium ion (NH4+) excretion with urine, 2) carbonic acid metabolism--with determination of urinary excretion of hydrogen ions (H+), 3) urinary excretion of sodium (Na+) and potassium (K+) ions. Besides that 24-hour urine was always measured. The studied women were similarly hydrated (standard diet, fluid balance control). The results were subjected to statistical analysis. In women with type I diabetes the volume of 24-hour urine was increased, although it fell within the normal range, urinary excretion of Na+ and K+ was raised. No change was found in amino-acid deamination an carbonic acid metabolism since the excretion of NH4+ and H+ was normal.
研究组包括47名处于妊娠晚期（29 - 40周）的女性，其中17名患有I型糖尿病（研究组），30名健康女性（对照组）。在研究组中，1例在孕期被诊断为糖尿病，仅通过饮食治疗，其余16名孕妇糖尿病平均病程为6.2年，平均每日胰岛素剂量为70单位。根据怀特分类法，1例为A类，10例为B类，6例为C类。所有病例肾功能均正常，肌酐、尿素、电解质、尿酸、蛋白质及酸碱平衡的血液值均正常。内生肌酐清除率也正常。所研究的肾小管功能生化参数包括：1）氨基酸脱氨基作用——通过测量尿中铵离子（NH4+）排泄量；2）碳酸代谢——通过测定尿中氢离子（H+）排泄量；3）尿中钠（Na+）和钾（K+）离子排泄量。除此之外，总是测量24小时尿量。所研究的女性水合状态相似（标准饮食，控制液体平衡）。对结果进行统计学分析。I型糖尿病女性24小时尿量增加，尽管仍在正常范围内，尿中Na+和K+排泄量升高。由于NH4+和H+排泄正常，氨基酸脱氨基作用和碳酸代谢未发现变化。
