Otsuki Mika
Nihon Rinsho. 2016 Mar;74(3):459-65.
This article provides an overview of the historical entity hitherto, the pivotal clinical symptoms of FTLD (frontotemporal lobar degeneration), and an introduction for the revised criteria for bvFTD (behavioral variant frontotemporal dementia): FTDC (International Behavioral Variant FTD Criteria Consortium) presented by Rascovsky et al(2011), and the classification criteria for PPA(primary progressive aphasia) heralded by Gorno-Tempini et al (2011). According to the former criteria, bvFTD can be diagnosed by the clinical symptoms as having possible bvFTD or probable bvFTD, and the pathological findings could lead definite bvFTD. In the latter classification criteria of PPA, two types are implicated in FTLD: one is the non-fluent/agrammatic variant PPA(PNFA/nfvPPA/naPPA), and the other is semantic variant PPA(SD/svPPA).
本文概述了迄今为止的历史实体、额颞叶变性(FTLD)的关键临床症状,并介绍了行为变异型额颞叶痴呆(bvFTD)的修订标准:Rascovsky等人(2011年)提出的FTDC(国际行为变异型FTD标准联盟),以及Gorno-Tempini等人(2011年)公布的原发性进行性失语(PPA)的分类标准。根据前一标准,bvFTD可通过临床症状诊断为可能的bvFTD或很可能的bvFTD,而病理结果可确诊bvFTD。在PPA的后一分类标准中,FTLD涉及两种类型:一种是非流利/语法缺失型PPA(PNFA/nfvPPA/naPPA),另一种是语义变异型PPA(SD/svPPA)。