T细胞受体信号传导在调节性T细胞分化和功能的控制中
T cell receptor signalling in the control of regulatory T cell differentiation and function.
作者信息
Li Ming O, Rudensky Alexander Y
机构信息
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Immunology Program, Howard Hughes Medical Institute and Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
出版信息
Nat Rev Immunol. 2016 Apr;16(4):220-33. doi: 10.1038/nri.2016.26.
Abstract
Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of TReg cells in the context of their function in health and disease.
摘要
调节性T细胞（TReg细胞）是一种特殊的T细胞谱系，在自身耐受性和炎症反应的控制中起关键作用。最近的研究揭示了一种独特的T细胞受体（TCR）信号传导模式，该模式调节TReg细胞的分化、维持和功能，并影响这些细胞的基因表达、代谢、细胞黏附和迁移。在这里，我们结合TReg细胞在健康和疾病中的功能，讨论对TCR引导的TReg细胞分化的新认识。
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