Calza L, Colangeli V, Magistrelli E, Manfredi R, Bon I, Re M C, Viale P
Department of Medical and Surgical Sciences, Section of Infectious Diseases, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
Department of Specialized, Diagnostic and Experimental Medicine, Section of Microbiology, "Alma Mater Studiorum" University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
HIV Med. 2016 Sep;17(8):631-3. doi: 10.1111/hiv.12374. Epub 2016 Mar 29.
Recent clinical studies and one meta-analysis have shown a modest but significant increase in the incidence of diabetes mellitus associated with statin exposure, so this correlation was investigated in a cohort of HIV-positive subjects.
A retrospective cohort study including adult HIV-1-infected patients followed at our Clinic of Infectious Diseases between 2007 and 2014 was performed.
We assessed 3170 HIV-positive patients with a median follow-up of 5.2 years. The incidence of diabetes mellitus was 1.2 per 100 person-years and it was not significantly associated with the prescription of statins [hazard ratio (HR) 1.09 per year of statin exposure; 95% confidence interval (CI) 0.7-1.49; P = 0.067], while it was associated with older age, chronic hepatitis C, antiretroviral-naïve vs. antiretroviral experienced condition, high body mass index, and high serum concentration of triglycerides.
In our study, a higher risk of diabetes mellitus was not associated with statin treatment, but with some traditional risk factors.
近期的临床研究和一项荟萃分析表明，与他汀类药物暴露相关的糖尿病发病率有适度但显著的增加，因此在一组HIV阳性受试者中对这种相关性进行了调查。
进行了一项回顾性队列研究，纳入了2007年至2014年期间在我们传染病诊所接受随访的成年HIV-1感染患者。
我们评估了3170名HIV阳性患者，中位随访时间为5.2年。糖尿病发病率为每100人年1.2例，与他汀类药物的处方无显著相关性[他汀类药物暴露每年的风险比（HR）为1.09；95%置信区间（CI）为0.7-1.49；P = 0.067]，而与年龄较大、慢性丙型肝炎、未接受抗逆转录病毒治疗与接受过抗逆转录病毒治疗的状态、高体重指数和高血清甘油三酯浓度相关。
在我们的研究中，糖尿病风险较高与他汀类药物治疗无关，而是与一些传统风险因素有关。
