蜂蜜对头颈部恶性肿瘤患者放射性口腔黏膜炎的疗效、发生黏膜炎的时间、体重减轻及治疗中断情况：一项文献的荟萃分析和系统评价
Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature.
作者信息
Co Jayson L, Mejia Michael Benedict A, Que Jocelyn C, Dizon Janine Margarita R
机构信息
Department of Radiation Oncology, Benavides Cancer Institute, University of Santo Tomas Hospital, Manila, Philippines.
Center for Pain Medicine, University of Santo Tomas Faculty of Medicine and Surgery, Benavides Cancer Institute, University of Santo Tomas Hospital, Manila, Philippines.
出版信息
Head Neck. 2016 Jul;38(7):1119-28. doi: 10.1002/hed.24431. Epub 2016 Mar 29.
BACKGROUND
Mucositis is a disabling effect of radiotherapy in head and neck cancers. There is no current standard on management of radiation-induced mucositis. Honey has been shown to reduce radiation-induced mucositis.
METHODS
A systematic review and meta-analysis were undertaken to assess the ability of honey in reducing the severity of oral mucositis, time to mucositis, weight loss, and treatment interruptions.
RESULTS
Eight studies were included and showed that honey was significantly better in lowering the risk for treatment interruptions, weight loss, and delaying time to mucositis, but not severity of mucositis.
CONCLUSION
There is current evidence that honey is beneficial for patients with head and neck cancers by decreasing treatment interruptions, weight loss, and delaying the onset of oral mucositis, but not in decreasing peak mucositis score. In light of the results, honey is a reasonable treatment for radiation-induced mucositis, but more randomized clinical trials (RCTs) should be done. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1119-1128, 2016.
背景
黏膜炎是头颈部癌症放射治疗的一种致残效应。目前对于放射性黏膜炎的管理尚无标准。已表明蜂蜜可减轻放射性黏膜炎。
方法
进行了一项系统评价和荟萃分析，以评估蜂蜜在降低口腔黏膜炎严重程度、出现黏膜炎的时间、体重减轻和治疗中断方面的能力。
结果
纳入了八项研究，结果显示蜂蜜在降低治疗中断风险、体重减轻以及延迟出现黏膜炎的时间方面明显更优，但在减轻黏膜炎严重程度方面并非如此。
结论
目前有证据表明，蜂蜜对患有头颈部癌症的患者有益，可减少治疗中断、减轻体重减轻并延迟口腔黏膜炎的发作，但不能降低黏膜炎的峰值评分。鉴于这些结果，蜂蜜是治疗放射性黏膜炎的一种合理方法，但应开展更多随机临床试验（RCT）。© 2016 威利期刊公司。《头颈》38: 1119 - 1128, 2016 年。
Zotero 插件