Grouls V, Stein U, Vogel J
Institut für Pathologie, Universität Bonn.
Dtsch Med Wochenschr. 1989 Apr 14;114(15):584-8. doi: 10.1055/s-2008-1066639.
A juxtapapillary duodenal polyp (measuring 1.5 x 1.0 x 1.2 cm) was removed endoscopically in a 57-year-old man who had had recurrent intestinal bleedings. Histological examination revealed a typical duodenal gangliocytic paraganglioma with carcinoid and paraganglioma-like components, as well as neuroid portions with ganglion cells. Various neuroendocrine markers (neuron-specific enolase, chromogranin, protein-gene product 9.5) were demonstrated immunohistochemically. Tests for pancreatic polypeptide, substance P, enkephalin, cholecystokinin, glucagon and S-100 proteins, were all positive.
一名57岁反复出现肠道出血的男性患者经内镜切除了一个十二指肠乳头旁息肉（大小为1.5×1.0×1.2厘米）。组织学检查显示为典型的十二指肠神经节细胞副神经节瘤，伴有类癌和副神经节瘤样成分，以及含有神经节细胞的神经样部分。免疫组织化学检测显示多种神经内分泌标志物（神经元特异性烯醇化酶、嗜铬粒蛋白、蛋白基因产物9.5）呈阳性。胰多肽、P物质、脑啡肽、胆囊收缩素、胰高血糖素和S-100蛋白检测均为阳性。
