Li Z J, Zhang Z K, Zhou S, Geng Q B, Sun J L, Zhou X N, Yang W Z
Key Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Apr;50(4):306-11. doi: 10.3760/cma.j.issn.0253-9624.2016.04.005.
To investigate the epidemiological characteristics and impact factors on hospitalization of Plasmodium vivax (P.vivax) since initiation of national malaria elimination program, so as to facilitate the adjustment of technical guideline in response to the epidemic changing of malaria in China.
The data of individual P. vivax case (probable and confirmed) and population during 2011-2014 were collated from China National Notifiable Infectious Disease Reporting Information System, and the data of epidemiological investigation for individual P. vivax case (imported and indigenous) during 2011-2014 were collected from China Parasite Disease Prevention and Control Information System. All of the data didn't include China's Hongkong, Macao, Taiwan and foreign cases. The risk factors on hospitalization were explored by multiple factors variable binary classification unconditioned logistic regression model.
During study period of four years, a total of 5 656 Plasmodium vivax cases were detected. Among them, 69.9% (3 951 cases) were imported cases and 30.1% (1 705 cases) were autochthonous cases. The male cases accounted for 82.7% of all cases. Among the autochthonous cases, 535 cases (31.4%) occurred in the cross-bordering areas, and 577 cases (33.8%) were reported in the junction of difference provinces. The amount of autochthonous cases decreased from 1 363 cases in 2011 to 53 cases in 2014, and the county affected by autochthonous cases was shrunk from 185 counties to 10 counties. The proportion of autochthonous cases introduced by domestic migrants increased constantly, which reached 41.5% in 2014. The imported cases were detected from 614 counties of 30 provinces, who were originated from 57 overseas countries of 4 continents, with Southeast Asia being the leading origins (2 772 cases, 70.2%). There were 1 494 cases hospitalized for treatment, with the male (OR=1.41, 95%CI: 1.16-1.71), 14 years old and younger (OR=2.26, 95%CI: 1.44-3.56), and oversea imported cases (OR=2.73, 95%CI: 2.30-3.25) were the high risk group for hospitalization.
The scale and scope of P. vivax occurrence decreased dramatically since initiation of malaria elimination grogram in 2010. However, the risk of P. vivax introduction by the overseas imported cases and domestic migrants should be highlighted.
了解全国疟疾消除规划实施以来间日疟的流行特征及影响住院的因素，为调整技术方案以应对我国疟疾流行形势变化提供依据。
收集中国疾病预防控制信息系统中2011-2014年间日疟（疑似和确诊）个案及人口数据，以及中国寄生虫病预防控制信息系统中2011-2014年间日疟（输入性和本地感染）个案流行病学调查数据。所有数据不包括中国香港、澳门、台湾地区及外籍病例。采用多因素变量二分类非条件Logistic回归模型探索影响住院的危险因素。
4年间共检测到间日疟病例5656例，其中输入性病例3951例（69.9%），本地感染病例1705例（30.1%）。男性病例占总病例数的82.7%。本地感染病例中，535例（31.4%）发生在边境地区，577例（33.8%）报告于省界交界处。本地感染病例数从2011年的1363例降至2014年的53例，受本地感染病例影响的县从185个减至10个。本地感染病例中由国内流动人口输入的比例不断上升，2014年达41.5%。输入性病例来自30个省的614个县，源自4大洲57个国家，东南亚地区为主要来源地（2772例，70.2%）。住院治疗1494例，男性（OR=1.41，95%CI：1.16-1.71）、14岁及以下儿童（OR=2.26，95%CI：1.44-3.56）和输入性病例（OR=2.73，95%CI：2.30-3.25）为住院高危人群。
2010年疟疾消除规划实施以来，间日疟发病规模和范围显著下降，但仍需关注输入性病例及国内流动人口输入间日疟的风险。
