Silingardi V, Davolio-Marani S, Federico M, Piccinini L, Frassoldati A, Sarti M, Burani A, Canossi G
Department of Medical Pathology, University of Modena, Italy.
Eur J Cancer Clin Oncol. 1989 Feb;25(2):209-13. doi: 10.1016/0277-5379(89)90010-2.
Magnetic resonance imaging (MRI) can detect bone marrow infiltration by neoplastic cells in many hematological malignancies. We studied 10 patients affected by hairy cell leukemia (HCL) and treated with interferon (IFN) with both MRI and bone marrow biopsy. T1-weighted MR scans of femurs and pelvis proved to be effective to score hairy cell infiltration, while less information was obtained from the study of the lumbar vertebral column. A good correlation (less than 10% difference) was noted between biopsy and MRI in over 90% of cases. MR scans showed, in general, a higher grade of infiltration. MR scan, however, can be useful for monitoring the course of HCL and the response to the treatment. Moreover, MRI evaluating a large amount of tissue, can detect a nodular type of infiltration which can be missed in biopsy specimens.
磁共振成像（MRI）能够在多种血液系统恶性肿瘤中检测到肿瘤细胞对骨髓的浸润。我们对10例毛细胞白血病（HCL）患者进行了研究，这些患者接受了干扰素（IFN）治疗，并同时接受了MRI和骨髓活检。股骨和骨盆的T1加权磁共振扫描被证明在评估毛细胞浸润程度方面是有效的，而从腰椎的研究中获得的信息较少。在超过90%的病例中，活检和MRI之间存在良好的相关性（差异小于10%）。一般来说，磁共振扫描显示出更高程度的浸润。然而，MRI可用于监测HCL的病程及对治疗的反应。此外，MRI能够评估大量组织，可检测到活检标本中可能遗漏的结节型浸润。
