Bargiacchi Olivia, De Rosa Francesco Giuseppe
Infectious Diseases Section, Maggiore della Carità Hospital, Novara, Italy.
Department of Medical Sciences, University of Turin, Infectious Diseases Section at Amedeo di Savoia Hospital, Turin, Italy.
Infez Med. 2016;24(1):3-11.
Central Nervous System (CNS) infections related to external ventricular derivation are a major complication of patients undergoing neurosurgical procedures. Antimicrobial treatment of CNS infections should be based not only on the susceptibility of the isolated microorganism, but also on the treatment's pharmacokinetic properties demonstrating the passage of the molecule through the blood-brain barrier. When CNS infections are caused by multi-drug resistant Gram-negative bacteria, intrathecal colistin is considered an effective and safe option. We review the literature of intrathecal/intraventricular use of colistin, comprehensive of both pharmacokinetic data and clinical experiences.
与外部脑室引流相关的中枢神经系统（CNS）感染是接受神经外科手术患者的主要并发症。中枢神经系统感染的抗菌治疗不仅应基于分离出的微生物的药敏情况，还应基于能证明药物分子通过血脑屏障的治疗药物动力学特性。当中枢神经系统感染由耐多药革兰氏阴性菌引起时，鞘内注射黏菌素被认为是一种有效且安全的选择。我们综述了黏菌素鞘内/脑室内使用的文献，包括药代动力学数据和临床经验。
