组织工程中的血管生成和血管形成：超越静态网络的构建。
Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks.
机构信息
Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02319, USA; Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02319, USA; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA, 02155, USA; College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.
出版信息
Trends Biotechnol. 2016 Sep;34(9):733-745. doi: 10.1016/j.tibtech.2016.03.002. Epub 2016 Mar 28.
Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capillaries, and arterioles, to supply all of the cells with sufficient nutrients. Owing to the importance of vascularization for the clinical applicability of tissue engineering, many approaches have been investigated to include an organized vascular network in tissue constructs. This review will give an overview of recent efforts, and will propose future perspectives to engineer the optimal, functional vascular network.
工程化组织需要血管网络在植入后为细胞提供营养和氧气。在体外培养过程中，可以包含一种在植入后能与患者脉管系统连接的网络。为了实现最佳的整合，这个网络需要高度组织化，包括小静脉、毛细血管和小动脉，以向所有细胞提供充足的营养。由于血管生成对于组织工程的临床应用至关重要，因此已经研究了许多方法来将有组织的血管网络纳入组织构建物中。这篇综述将概述最近的研究进展，并提出未来构建最佳功能血管网络的观点。
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