Ducimetiere P, Richard J L
Groupe d'Etude sur l'Epidémologie de l'Athérosclérose, Paris, France.
Int J Obes. 1989;13(1):111-21.
The importance of body fat distribution as one determinant of various metabolic disorders associated with obesity is now recognized and some epidemiological evidence exists that it might be related to the onset of coronary heart disease (CHD) in men and women. The Paris Prospective Study data permitted exploration of the relationship between three subsets of anthropometric upper versus lower body measurements (waist-thigh circumferences, subumbilical-thigh skinfolds, bideltoid-bitrochanter diameters) and CHD risk in a middle-aged male population. The analysis successively disclosed the simple measurement ratio for both girth and diameters and the subumbilical2: thigh skinfold ratio as the best predictors of CHD outcome. The girth and skinfold but not the diameter ratios were positively correlated with body mass index and usual CHD risk factors except smoking. The relationship of upper versus lower fat localization (girth and skinfold ratios) with CHD incidence confirmed previous results obtained in this population but its magnitude is low in comparison with usual CHD risk factors. The association of the diameter ratio as an index of upper body frame with CHD occurrence remains to be confirmed by further studies.
身体脂肪分布作为与肥胖相关的各种代谢紊乱的一个决定因素,其重要性现已得到认可,并且有一些流行病学证据表明,它可能与男性和女性冠心病(CHD)的发病有关。巴黎前瞻性研究数据有助于探索人体测量学中上身与下身测量的三个子集(腰围与大腿围、脐下与大腿皮褶、双侧三角肌与双侧大转子直径)与中年男性人群冠心病风险之间的关系。分析相继揭示,周长和直径的简单测量比值以及脐下2:大腿皮褶比值是冠心病结局的最佳预测指标。周长和皮褶比值而非直径比值与体重指数及除吸烟外的常见冠心病危险因素呈正相关。上身与下身脂肪定位(周长和皮褶比值)与冠心病发病率之间的关系证实了此前在该人群中获得的结果,但与常见冠心病危险因素相比,其关联程度较低。作为上身框架指标的直径比值与冠心病发生之间的关联仍有待进一步研究证实。