Hong A, Rojas A, Dische S
Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):1097-9. doi: 10.1016/0360-3016(89)90925-5.
A series of experiments have been performed to determine the relative radiosensitivities of a mouse mammary tumor (CA NT) irradiated in 100% normobaric oxygen or in air, using clinically relevant dose-fractionation schedules. The results demonstrate that normobaric oxygen is a potent radiosensitizer, its effect being more marked with smaller size fractions. Enhancement ratios (ER) of 1.23 to 1.45 were obtained. By contrast, no significant benefit was seen with single doses (ER = 1.05 +/- 0.14). The degree of radiosensitization with oxygen, in these fractionated regimens, is greater than that reported for the chemical radiosensitizer, misonidazole. It therefore seems appropriate to re-examine the clinical potential of normobaric oxygen and to consider how the conditions of normobaric radiotherapy achieved in the laboratory can be translated to man.
已经进行了一系列实验，以确定在100%常压氧气或空气中照射的小鼠乳腺肿瘤（CA NT）的相对放射敏感性，采用临床相关的剂量分割方案。结果表明，常压氧气是一种有效的放射增敏剂，其效果在较小的剂量分割时更为明显。获得了1.23至1.45的增强比（ER）。相比之下，单次剂量未观察到显著益处（ER = 1.05 +/- 0.14）。在这些分割方案中，氧气的放射增敏程度大于化学放射增敏剂米索硝唑的报道程度。因此，重新审视常压氧气的临床潜力并考虑如何将实验室中实现的常压放射治疗条件转化应用于人体似乎是合适的。
