Lu Shelly C, Mato José M, Espinosa-Diez Cristina, Lamas Santiago
Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
CIC bioGUNE, (CIBERehd), Parque Tecnológico de Bizcaia, Derio, Spain.
Free Radic Biol Med. 2016 Nov;100:66-72. doi: 10.1016/j.freeradbiomed.2016.03.021. Epub 2016 Mar 24.
The discovery of the microRNA (miRNA) family of small RNAs as fundamental regulators of post-transcriptional gene expression has fostered research on their importance in every area of biology and clinical medicine. In the particular area of liver metabolism and disease, miRNAs are gaining increasing importance. By focusing on two fundamental hepatic biosynthetic pathways, glutathione and methionine, we review recent advances on the comprehension of the role of miRNAs in liver pathophysiology and more specifically of models of hepatic cholestasis/fibrosis and hepatocellular carcinoma.
微小RNA(miRNA)家族作为转录后基因表达的基本调节因子的发现,推动了关于它们在生物学和临床医学各个领域重要性的研究。在肝脏代谢和疾病这一特定领域,miRNA正变得越来越重要。通过聚焦于两条基本的肝脏生物合成途径,即谷胱甘肽和蛋氨酸途径,我们综述了近期在理解miRNA在肝脏病理生理学中的作用方面取得的进展,更具体地说,是在肝内胆汁淤积/纤维化和肝细胞癌模型方面的进展。