基因组异常驱动神经内分泌肿瘤的克隆进化。
Genomic Aberrations Drive Clonal Evolution of Neuroendocrine Tumors.
机构信息
Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA.
Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Trends Endocrinol Metab. 2016 May;27(5):242-244. doi: 10.1016/j.tem.2016.03.009. Epub 2016 Mar 29.
Molecular features of castration-resistant neuroendocrine prostate cancer (CRPC-NE) are not well characterized. A recent study that investigated genomic aberrations of CRPC-NE tumors suggests their clonal evolution from CRPC adenocarcinoma. Furthermore, the existence of a distinct DNA methylation profile in CRPC-NE implicates a critical role for epigenetic modification in the development of CRPC-NE.
去势抵抗性神经内分泌前列腺癌（CRPC-NE）的分子特征尚未得到很好的描述。最近的一项研究调查了 CRPC-NE 肿瘤的基因组异常，表明它们是从 CRPC 腺癌中克隆进化而来的。此外，CRPC-NE 中存在独特的 DNA 甲基化谱，这表明表观遗传修饰在 CRPC-NE 的发展中起着关键作用。
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