Ramezani Mazaher, Abdali Elham, Khazaei Sedigheh, Vaisi-Raygani Asad, Sadeghi Masoud
Molecular Pathology Research Center, Emam Reza University Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(3):1093-6. doi: 10.7314/apjcp.2016.17.3.1093.
The tumor suppressor p16 is a biomarker for transforming human papilloma virus (HPV) infections that can lead to contradictory results in skin carcinomas. The aim of this study was to evaluate p16 expression and HPV-16 infection in the cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This case-control study was performed on paraffin blocks of BCCs and SCCs and normal skin (53, 36, and 44 cases, respectively), between 2006 to 2015. Initial sections for groups were stained with hematoxylin and eosin (H and E). Immunohistochemistry was performed for p16 expression and human papilloma virus type 16 (HPV-16) infection. Normal group was skin of mammoplasty specimens and normal skin tissue in the periphery of tumors. The mean age at diagnosis was 42.1, 61.7 and 71.4 years for normal, BCC and SCC groups, respectively. P16 positivity was more in SCC and BCC groups compared to normal group (P<0.05) and HPV was negative in all patients in three groups. Also, the mean age at diagnosis and P16-positivity were higher for the SCC group than the BCC group (P<0.005). In conclusion, in non-melanoma skin cancers (SCC and BCC), p16-positivity can be a prognostic factor but there is no correlation between HPV-16 and p16 in these tumors.
肿瘤抑制因子p16是一种用于检测人乳头瘤病毒（HPV）感染的生物标志物，而HPV感染在皮肤癌中可能会导致相互矛盾的结果。本研究旨在评估皮肤基底细胞癌（BCC）和鳞状细胞癌（SCC）中p16的表达及HPV-16感染情况。本病例对照研究于2006年至2015年间，对BCC、SCC石蜡块及正常皮肤（分别为53例、36例和44例）进行。各组初始切片用苏木精和伊红（H&E）染色。采用免疫组织化学方法检测p16表达及人乳头瘤病毒16型（HPV-16）感染情况。正常组为乳房成形术标本皮肤及肿瘤周边的正常皮肤组织。正常组、BCC组和SCC组的平均诊断年龄分别为42.1岁、61.7岁和71.4岁。与正常组相比，SCC组和BCC组的p16阳性率更高（P<0.05），三组所有患者的HPV均为阴性。此外，SCC组的平均诊断年龄和p16阳性率均高于BCC组（P<0.005）。总之，在非黑色素瘤皮肤癌（SCC和BCC）中，p16阳性可能是一个预后因素，但在这些肿瘤中HPV-16与p16之间无相关性。
